Mitochondrial Dysfunction in Neurodegenerative Diseases
Keywords:
mitochondria, neurodegenerative processes, programmed cell death, endoplasmic reticulum stress. Key words: mitochondria, neurodegenerative processes, programmed cell death, stress of endoplasmic reticulum.Abstract
This review discusses the following mechanisms damage and dysregulatory effects on mitochondria: activation of nonspecific response mechanisms to disruption of the native structure of proteins – unfolded protein response (UPR); loss of mitochondrial function proteins; direct toxic effects of defective proteins on mitochondria; mitochondrial activation PGK mechanisms; dysregulation of the processes of utilization, division and fusion of mitochondria; traffic disruption and intracellular distribution of mitochondria.
